Rb (Acetyl-K873/K874) Rabbit Polyclonal Antibody

Name: Rb (Acetyl-K873/K874) Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES8829
Price: 248.0 USD
Availability: InStock

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Rb (Acetyl-K873/K874) Rabbit Polyclonal Antibody

Overview

Product name:	Rb (Acetyl-K873/K874) rabbit pAb
Alternative Names:	Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)
Applications:	WB;IHC
Recommended Dilutions:	WB 1:500-2000;IHC-p 1:50-300
Immunogen:	Synthesized Acetyl peptide derived from human Rb. at AA range: K873/872
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
GeneID（Human）:	5925
Human Swiss-Prot No:	P06400
Cellular localization:	Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .
Background:	The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
Species Reactivity:	Human:K873+K874;Mouse:K866+K867;Rat:K865+K866

Western Blot analysis of 1,mouse-heart 3,mouse-brain cells using primary antibody diluted at 1:1000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

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Rb (Acetyl-K873/K874) Rabbit Polyclonal Antibody

Rb (Acetyl-K873/K874) Rabbit Polyclonal Antibody

Overview