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ELK Biotechnology
SKU:ES8817
LIM and SH3 domain protein 1 Rabbit Polyclonal Antibody
LIM and SH3 domain protein 1 Rabbit Polyclonal Antibody
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LIM and SH3 domain protein 1 Rabbit Polyclonal Antibody
Overview
| Product name: | LIM and SH3 domain protein 1 rabbit pAb |
| Alternative Names: | LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50) |
| Applications: | WB;IHC |
| Recommended Dilutions: | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen: | Synthesized peptide derived from human LIM and SH3 domain protein 1. at AA range: 90-130 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 38kD |
| GeneID(Human): | 3927 |
| Human Swiss-Prot No: | Q14847 |
| Cellular localization: | Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Associated with the F-actin rich cortical cytoskeleton. . |
| Background: | This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012], |
| Species Reactivity: | Human;Mouse;Rat |
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night -
Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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