Programmed cell death 1 ligand 2 (PD-1 ligand 2;PD-L2;PDCD1 ligand 2;Programmed death ligand 2;Butyrophilin B7-DC;B7-DC;CD antigen CD273)
Applications:
WB;IHC;IF;ELISA
Recommended Dilutions:
WB 1:500-2000,IHC-p 1:50-200, ELISA 1:10000-20000
Immunogen:
Synthetic peptide from human protein at AA range: 31-80
Storage:
Rabbit
Storage:
-20°C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Observed Band:
30kD
GeneID（Human）:
80380
Human Swiss-Prot No:
Q9BQ51
Cellular localization:
[Isoform 3]: Secreted .; [Isoform 2]: Endomembrane system ; Single-pass type I membrane protein .; [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .
Background:
function:Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.,induction:Up-regulated by IFNG stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4.,similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PDCD1.,tissue specificity:Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.,
