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ELK Biotechnology

ES8492

IgM Chain C Rabbit Polyclonal Antibody

IgM Chain C Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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IgM Chain C Rabbit Polyclonal Antibody

Overview

Product name: IgM Chain C rabbit pAb
Alternative Names: Ig mu chain C region
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000
Immunogen: Synthesized peptide derived from IgM Chain C at AA range: 391-440
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 50kD
Human Swiss-Prot No: P01871
Cellular localization: [Isoform 1]: Secreted. During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
Background: Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which d
Species Reactivity: Human;Mouse;Rat
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