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ELK Biotechnology

ES8477

PI 3 Kinase Class 3 Rabbit Polyclonal Antibody

PI 3 Kinase Class 3 Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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PI 3 Kinase Class 3 Rabbit Polyclonal Antibody

Overview

Product name: PI 3 Kinase Class 3 rabbit pAb
Alternative Names: phosphoinositide-3-kinase, class 3
Applications: WB;IHC
Recommended Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: Synthetic Peptide of PI 3 Kinase Class 3
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 100kD
GeneID（Human）: 5289
Human Swiss-Prot No: Q8NEB9
Cellular localization: Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). .
Background: catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.,cofactor:Manganese.,function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4.,tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle.,
Species Reactivity: Human;Mouse;Rat;Predicted:Cow:PIG
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