1 1

ELK Biotechnology

ES8081

MDC1 (phospho Ser513) Rabbit Polyclonal Antibody

MDC1 (phospho Ser513) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
Sale Sold out
Shipping calculated at checkout.
Size

MDC1 (phospho Ser513) Rabbit Polyclonal Antibody

Overview

Product name: MDC1 (phospho Ser513) rabbit pAb
Alternative Names: MDC1; KIAA0170; NFBD1; Mediator of DNA damage checkpoint protein 1; Nuclear factor with BRCT domains 1
Applications: IHC;IF;ELISA
Recommended Dilutions: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human MDC1 around the phosphorylation site of Ser513. AA range:479-528
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
GeneID（Human）: 9656
Human Swiss-Prot No: Q14676
Cellular localization: Nucleus . Chromosome . Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AX. Colocalizes with APTX at sites of DNA double-strand breaks.
Background: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Rat;Mouse;
View full details