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ELK Biotechnology

ES7887

HDAC3 (phospho Ser424) Rabbit Polyclonal Antibody

HDAC3 (phospho Ser424) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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HDAC3 (phospho Ser424) Rabbit Polyclonal Antibody

Overview

Product name: HDAC3 (phospho Ser424) rabbit pAb
Alternative Names: HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human HDAC3 around the phosphorylation site of Ser424. AA range:379-428
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 48kD
GeneID（Human）: 8841
Human Swiss-Prot No: O15379
Cellular localization: Nucleus . Cytoplasm . Cytoplasm, cytosol . Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). .
Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Mouse;Rat
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