Cleaved-Caspase-1 (D210) Rabbit Polyclonal Antibody

Name: Cleaved-Caspase-1 (D210) Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES7675
Price: 248.0 USD
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Cleaved-Caspase-1 (D210) Rabbit Polyclonal Antibody

Overview

Product name:	Cleaved-Caspase-1 p20 (D210) rabbit pAb
Alternative Names:	CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45
Applications:	WB;IF;IHC;ELISA
Recommended Dilutions:	WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
Immunogen:	The antiserum was produced against synthesized peptide derived from human Caspase-1. AA range:161-210
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	25kD
GeneID（Human）:	834
Human Swiss-Prot No:	P29466
Cellular localization:	Cytoplasm . Cell membrane .
Background:	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],
Species Reactivity:	Human;Mouse;Rat

Immunofluorescence analysis of A549. 1,primary Antibody(red) was diluted at 1:200(4°C overnight). 2, Goat Anti Rabbit IgG (H&L) - Alexa Fluor 594 Secondary antibody was diluted at 1:1000(room temperature, 50min).3, Picture B: DAPI(blue) 10min.
Immunohistochemical analysis of paraffin-embedded Human-breast tissue. 1,Cleaved-Caspase-1 (D210) Polyclonal Antibody was diluted at 1:200(4°C,overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3,Secondary antibody was dilu
Immunohistochemical analysis of paraffin-embedded Human-breast-cancer tissue. 1,Cleaved-Caspase-1 (D210) Polyclonal Antibody was diluted at 1:200(4°C,overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3,Secondary antibody w
Immunohistochemical analysis of paraffin-embedded Human-liver tissue. 1,Cleaved-Caspase-1 (D210) Polyclonal Antibody was diluted at 1:200(4°C,overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3,Secondary antibody was dilut

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Cleaved-Caspase-1 (D210) Rabbit Polyclonal Antibody

Cleaved-Caspase-1 (D210) Rabbit Polyclonal Antibody

Overview