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ELK Biotechnology

ES7485

Vav (phospho Tyr174) Rabbit Polyclonal Antibody

Vav (phospho Tyr174) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Vav (phospho Tyr174) Rabbit Polyclonal Antibody

Overview

Product name: Vav (phospho Tyr174) rabbit pAb
Alternative Names: VAV1; VAV; Proto-oncogene vav
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Vav (phospho Tyr174)
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 100kD
GeneID（Human）: 7409
Human Swiss-Prot No: P15498
Cellular localization: intracellular,cytosol,plasma membrane,cell-cell junction,
Background: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],
Species Reactivity: Human;Mouse;Rat
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