TTK (phospho Thr676) Rabbit Polyclonal Antibody

Name: TTK (phospho Thr676) Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES7458
Price: 248.0 USD
Availability: InStock

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TTK (phospho Thr676) Rabbit Polyclonal Antibody

Product name:	TTK (phospho Thr676) rabbit pAb
Alternative Names:	TTK; MPS1; MPS1L1; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT
Applications:	IHC;IF;ELISA
Recommended Dilutions:	Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human TTK around the phosphorylation site of Thr676. AA range:642-691
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
GeneID（Human）:	7272
Human Swiss-Prot No:	P33981
Cellular localization:	kinetochore,cytoplasm,spindle,membrane,
Background:	TTK protein kinase(TTK) Homo sapiens This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009],
Species Reactivity:	Human;Mouse

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