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ELK Biotechnology

ES7379

TGFβ RII (phospho Ser225) Rabbit Polyclonal Antibody

TGFβ RII (phospho Ser225) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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TGFβ RII (phospho Ser225) Rabbit Polyclonal Antibody

Overview

Product name: TGFβ RII (phospho Ser225) rabbit pAb
Alternative Names: TGFBR2; TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II
Applications: IHC;IF;ELISA
Recommended Dilutions: WB 1:500-2000 ,Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human TGF beta Receptor II around the phosphorylation site of Ser225/250. AA range:191-240
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 75kD
GeneID（Human）: 7048
Human Swiss-Prot No: P37173
Cellular localization: Cell membrane ; Single-pass type I membrane protein . Membrane raft .; [Isoform 3]: Secreted .
Background: This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Mouse
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