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ELK Biotechnology

ES7359

TDG Rabbit Polyclonal Antibody

TDG Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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TDG Rabbit Polyclonal Antibody

Overview

Product name: TDG rabbit pAb
Alternative Names: TDG; G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human TDG. AA range:31-80
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 46kD
GeneID（Human）: 6996
Human Swiss-Prot No: Q13569
Cellular localization: Nucleus .
Background: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Mouse;Rat
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