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ELK Biotechnology

ES7309

LKB1 (phospho Thr189) Rabbit Polyclonal Antibody

LKB1 (phospho Thr189) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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LKB1 (phospho Thr189) Rabbit Polyclonal Antibody

Overview

Product name: LKB1 (phospho Thr189) rabbit pAb
Alternative Names: STK11; LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19
Applications: WB;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human LKB1 around the phosphorylation site of Thr189. AA range:155-204
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 65kD
GeneID（Human）: 6794
Human Swiss-Prot No: Q15831
Cellular localization: Nucleus. Cytoplasm. Membrane . Mitochondrion. A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
Background: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Mouse
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