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ELK Biotechnology

ES7299

Stat5a (phospho Ser780) Rabbit Polyclonal Antibody

Stat5a (phospho Ser780) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Stat5a (phospho Ser780) Rabbit Polyclonal Antibody

Overview

Product name: Stat5a (phospho Ser780) rabbit pAb
Alternative Names: STAT5A; STAT5; Signal transducer and activator of transcription 5A
Applications: WB;IHC;IF;IP;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human STAT5A around the phosphorylation site of Ser780. AA range:745-794
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 91kD
GeneID（Human）: 6776
Human Swiss-Prot No: P42229
Cellular localization: Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation.
Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been
Species Reactivity: Human;Mouse;Rat
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