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ELK Biotechnology

ES7029

Renin Rabbit Polyclonal Antibody

Renin Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Renin Rabbit Polyclonal Antibody

Overview

Product name: Renin rabbit pAb
Alternative Names: REN; Renin; Angiotensinogenase
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human REN. AA range:207-256
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 40kD
GeneID（Human）: 5972
Human Swiss-Prot No: P00797
Cellular localization: Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
Background: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Rat;Mouse;
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