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ELK Biotechnology

ES7000

Rb (phospho Ser249) Rabbit Polyclonal Antibody

Rb (phospho Ser249) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Rb (phospho Ser249) Rabbit Polyclonal Antibody

Overview

Product name: Rb (phospho Ser249) rabbit pAb
Alternative Names: RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Applications: WB;ELISA;IHC
Recommended Dilutions: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen: The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser249. AA range:221-270
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
GeneID（Human）: 5925
Human Swiss-Prot No: P06400
Cellular localization: Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .
Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Mouse;Rat
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