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ELK Biotechnology
SKU:ES6881
Patched Rabbit Polyclonal Antibody
Patched Rabbit Polyclonal Antibody
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$248.00 USD
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Patched Rabbit Polyclonal Antibody
Overview
| Product name: | Patched rabbit pAb |
| Alternative Names: | PTCH1; PTCH; Protein patched homolog 1; PTC; PTC1 |
| Applications: | WB;IHC;IF;ELISA |
| Recommended Dilutions: | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Patched. AA range:1-50 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 160kD |
| GeneID（Human）: | 5727 |
| Human Swiss-Prot No: | Q13635 |
| Cellular localization: | Cell membrane ; Multi-pass membrane protein . |
| Background: | This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Mouse |
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