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ELK Biotechnology

ES6795

PKC θ (phospho Ser695) Rabbit Polyclonal Antibody

PKC θ (phospho Ser695) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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PKC θ (phospho Ser695) Rabbit Polyclonal Antibody

Overview

Product name: PKC θ (phospho Ser695) rabbit pAb
Alternative Names: PRKCQ; PRKCT; Protein kinase C theta type; nPKC-theta
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human PKC thet around the phosphorylation site of Ser695. AA range:657-706
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 85kD
GeneID（Human）: 5588
Human Swiss-Prot No: Q04759
Cellular localization: Cytoplasm. Cell membrane; Peripheral membrane protein. In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.
Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Rat;Mouse;
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