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ELK Biotechnology

ES6677

BCAS3 Rabbit Polyclonal Antibody

BCAS3 Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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BCAS3 Rabbit Polyclonal Antibody

Overview

Product name: BCAS3 rabbit pAb
Alternative Names: BCAS3; Breast carcinoma-amplified sequence 3; GAOB1
Applications: WB;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: Synthesized peptide derived from BCAS3 . at AA range: 660-740
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 100kD
GeneID（Human）: 54828
Human Swiss-Prot No: Q9H6U6
Cellular localization: Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Preautophagosomal structure . Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712). .
Background: developmental stage:Fetal.,disease:A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t(17;20)(q23;q13) with BCAS4.,similarity:Belongs to the WD repeat BCAS3 family.,similarity:Contains 3 WD repeats.,tissue specificity:Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.,
Species Reactivity: Human;Mouse
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