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ELK Biotechnology

ES6608

PLC γ2 (phospho Tyr1217) Rabbit Polyclonal Antibody

PLC γ2 (phospho Tyr1217) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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PLC γ2 (phospho Tyr1217) Rabbit Polyclonal Antibody

Overview

Product name: PLC γ2 (phospho Tyr1217) rabbit pAb
Alternative Names: PLCG2; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human PLCG2 around the phosphorylation site of Tyr1217. AA range:1186-1235
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 148kD
GeneID（Human）: 5336
Human Swiss-Prot No: P16885
Cellular localization: intracellular,cytosol,plasma membrane,extracellular exosome,
Background: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],
Species Reactivity: Human;Mouse;Rat
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