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ELK Biotechnology

ES6589

Pim-1 Rabbit Polyclonal Antibody

Pim-1 Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Pim-1 Rabbit Polyclonal Antibody

Overview

Product name: Pim-1 rabbit pAb
Alternative Names: PIM1; Serine/threonine-protein kinase pim-1
Applications: WB;IHC
Recommended Dilutions: WB 1:500-2000;IHC-p 1:50-300
Immunogen: The antiserum was produced against synthesized peptide derived from human Pim-1. AA range:281-330
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 50kD
GeneID（Human）: 5292
Human Swiss-Prot No: P11309
Cellular localization: [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane.
Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011],
Species Reactivity: Human;Mouse;Rat
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