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ELK Biotechnology
SKU:ES6583
P-glycoprotein 1 Rabbit Polyclonal Antibody
P-glycoprotein 1 Rabbit Polyclonal Antibody
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P-glycoprotein 1 Rabbit Polyclonal Antibody
Overview
| Product name: | P-glycoprotein 1 rabbit pAb |
| Alternative Names: | p-pg;ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243 |
| Applications: | WB;IHC;IF;ELISA |
| Recommended Dilutions: | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human P-glycoprotein 1. AA range:534-583 |
| Storage: | -20°C/1 year |
| Storage: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| GeneID（Human）: | 5243 |
| Human Swiss-Prot No: | P08183 |
| Cellular localization: | Cell membrane ; Multi-pass membrane protein . Apical cell membrane . |
| Background: | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Mouse;Rat |
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