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ELK Biotechnology

ES6491

Sclerostin Rabbit Polyclonal Antibody

Sclerostin Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Sclerostin Rabbit Polyclonal Antibody

Overview

Product name: Sclerostin rabbit pAb
Alternative Names: SOST; Sclerostin
Applications: WB;ELISA;IHC
Recommended Dilutions: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen: Synthesized peptide derived from Sclerostin . at AA range: 130-210
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 26kD
GeneID（Human）: 50964
Human Swiss-Prot No: Q9BQB4
Cellular localization: Secreted, extracellular space, extracellular matrix .
Background: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Rat;Mouse;
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