NFκB-p105/p50 Rabbit Polyclonal Antibody

Name: NFκB-p105/p50 Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES6376
Price: 248.0 USD
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NFκB-p105/p50 Rabbit Polyclonal Antibody

Overview

Product name:	NFκB-p105/p50 rabbit pAb
Alternative Names:	NFKB1; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Applications:	IF;WB;IHC;ELISA
Recommended Dilutions:	IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human NF-kappaB p105/p50. AA range:304-353
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
GeneID（Human）:	4790
Human Swiss-Prot No:	P19838
Cellular localization:	Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Background:	nuclear factor kappa B subunit 1(NFKB1) Homo sapiens This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof
Species Reactivity:	Human;Mouse;Rat

Immunofluorescence analysis of Hela cell. 1,NFκB-p105/p50 Polyclonal Antibody(red) was diluted at 1:200(4° overnight). GAPDH Monoclonal Antibody(2B8)(green) was diluted at 1:200(4° overnight). 2, Goat Anti Rabbit Alexa Fluor 594 Catalog:RS3611 was diluted
Immunofluorescence analysis of human-lung tissue. 1,NFκB-p105/p50 Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target
Immunofluorescence analysis of human-lung tissue. 1,NFκB-p105/p50 Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target
Immunohistochemical analysis of paraffin-embedded Human-Tonsil tissue. 1,NFκB-p105/p50 Polyclonal Antibody was diluted at 1:200(4°C,overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3,Secondary antibody was diluted at 1:20

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NFκB-p105/p50 Rabbit Polyclonal Antibody

NFκB-p105/p50 Rabbit Polyclonal Antibody

Overview