MRE11 (phospho Ser264) Rabbit Polyclonal Antibody

Name: MRE11 (phospho Ser264) Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES6268
Price: 248.0 USD
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MRE11 (phospho Ser264) Rabbit Polyclonal Antibody

Overview

Product name:	MRE11 (phospho Ser264) rabbit pAb
Alternative Names:	MRE11A; HNGS1; MRE11; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
Applications:	WB;ELISA;IHC
Recommended Dilutions:	WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen:	The antiserum was produced against synthesized peptide derived from human MRE11 around the phosphorylation site of Ser264. AA range:230-279
Storage:	-20°C/1 year
Storage:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	80kD
GeneID（Human）:	4361
Human Swiss-Prot No:	P49959
Cellular localization:	Nucleus . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents. .
Background:	This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Species Reactivity:	Human;Mouse;Rat

Western Blot analysis of 3T3 cells using Phospho-MRE11 (S264) Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Western blot analysis of lysates from NIH/3T3 cells treated with forskolin 40nM 30', using MRE11 (Phospho-Ser264) Antibody. The lane on the right is blocked with the phospho peptide.
Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

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MRE11 (phospho Ser264) Rabbit Polyclonal Antibody

MRE11 (phospho Ser264) Rabbit Polyclonal Antibody

Overview