1 1

ELK Biotechnology

ES6234

Met (phospho Tyr1003) Rabbit Polyclonal Antibody

Met (phospho Tyr1003) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
Sale Sold out
Shipping calculated at checkout.
Size

Met (phospho Tyr1003) Rabbit Polyclonal Antibody

Overview

Product name: Met (phospho Tyr1003) rabbit pAb
Alternative Names: MET; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human c-Met around the phosphorylation site of Tyr1003. AA range:976-1025
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 155kD
GeneID（Human）: 4233
Human Swiss-Prot No: P08581
Cellular localization: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
Background: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016],
Species Reactivity: Human;Mouse;Rat
View full details