KIR3.1 (phospho Ser185) Rabbit Polyclonal Antibody

Name: KIR3.1 (phospho Ser185) Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES6004
Price: 248.0 USD
Availability: InStock

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KIR3.1 (phospho Ser185) Rabbit Polyclonal Antibody

Overview

Product name:	KIR3.1 (phospho Ser185) rabbit pAb
Alternative Names:	KCNJ3; GIRK1; G protein-activated inward rectifier potassium channel 1; GIRK-1; Inward rectifier K(+) channel Kir3.1; Potassium channel; inwardly rectifying subfamily J member 3
Applications:	WB;IHC;IF;ELISA
Recommended Dilutions:	Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human GIRK1/KIR3.1/KCNJ3 around the phosphorylation site of Ser185. AA range:151-200
Storage:	-20°C/1 year
Storage:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	50kD
GeneID（Human）:	3760
Human Swiss-Prot No:	P48549
Cellular localization:	Membrane; Multi-pass membrane protein.
Background:	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, at
Species Reactivity:	Human;Mouse;Rat;Monkey

Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using GIRK1/KIR3.1/KCNJ3 (Phospho-Ser185) Antibody
Immunofluorescence analysis of HeLa cells, using GIRK1/KIR3.1/KCNJ3 (Phospho-Ser185) Antibody. The picture on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using GIRK1/KIR3.1/KCNJ3 (Phospho-Ser185) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from RAW264.7 cells treated with Insulin 0.01U/ml 15', using GIRK1/KIR3.1/KCNJ3 (Phospho-Ser185) Antibody. The lane on the right is blocked with the phospho peptide.

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KIR3.1 (phospho Ser185) Rabbit Polyclonal Antibody

KIR3.1 (phospho Ser185) Rabbit Polyclonal Antibody

Overview