IRF-3 (phospho Ser396) Rabbit Polyclonal Antibody

Name: IRF-3 (phospho Ser396) Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES5921
Price: 248.0 USD
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IRF-3 (phospho Ser396) Rabbit Polyclonal Antibody

Overview

Product name:	IRF-3 (phospho Ser396) rabbit pAb
Alternative Names:	IRF3; Interferon regulatory factor 3; IRF-3
Applications:	WB;IHC
Recommended Dilutions:	WB 1:500-2000;IHC-p 1:50-300
Immunogen:	The antiserum was produced against synthesized peptide derived from human IRF-3 around the phosphorylation site of Ser396. AA range:362-411
Storage:	-20°C/1 year
Storage:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	48-55kd
GeneID（Human）:	3661
Human Swiss-Prot No:	Q14653
Cellular localization:	Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .
Background:	This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],
Species Reactivity:	Human;Mouse;Rat

Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using IRF-3 (Phospho-Ser396) Antibody
Western blot analysis of lysates from Jurkat cells treated with EGF 200ng/ml 30', using IRF-3 (Phospho-Ser396) Antibody. The lane on the right is blocked with the phospho peptide.
Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

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IRF-3 (phospho Ser396) Rabbit Polyclonal Antibody

IRF-3 (phospho Ser396) Rabbit Polyclonal Antibody

Overview