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ELK Biotechnology

ES5891

IL-10Rα (phospho Tyr496) Rabbit Polyclonal Antibody

IL-10Rα (phospho Tyr496) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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IL-10Rα (phospho Tyr496) Rabbit Polyclonal Antibody

Overview

Product name: IL-10Rα (phospho Tyr496) rabbit pAb
Alternative Names: IL10RA; IL10R; Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD antigen CD210
Applications: WB;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human IL-10R alpha around the phosphorylation site of Tyr496. AA range:462-511
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 63kD
GeneID（Human）: 3587
Human Swiss-Prot No: Q13651
Cellular localization: Cell membrane ; Single-pass type I membrane protein. Cytoplasm .
Background: The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009],
Species Reactivity: Human;Rat;Mouse;
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