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ELK Biotechnology

ES5848

IGF-IR (phospho Tyr1346) Rabbit Polyclonal Antibody

IGF-IR (phospho Tyr1346) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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IGF-IR (phospho Tyr1346) Rabbit Polyclonal Antibody

Overview

Product name: IGF-IR (phospho Tyr1346) rabbit pAb
Alternative Names: IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221
Applications: IHC;IF;ELISA
Recommended Dilutions: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human IGF1R around the phosphorylation site of Tyr1346. AA range:1311-1360
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: pro: 155kD, recetor beta: 95kD
GeneID（Human）: 3480
Human Swiss-Prot No: P08069
Cellular localization: Cell membrane ; Single-pass type I membrane protein .
Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],
Species Reactivity: Human;Mouse;Rat
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