Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen:
The antiserum was produced against synthesized peptide derived from human NRG1 isoform-10. AA range:1-50
Storage:
Rabbit
Storage:
-20°C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Observed Band:
44kD
GeneID（Human）:
3084
Human Swiss-Prot No:
Q02297-10
Cellular localization:
[Pro-neuregulin-1, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Does not seem to be active.; [Neuregulin-1]: Secreted.; [Isoform 8]: Nucleus. May be nuclear.; [Isoform 9]: Secreted. Has a signal peptide.; [Isoform 10]: Membrane; Single-pass type I membrane protein. May possess an internal uncleaved signal sequence.
Background:
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016],
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using NRG1 isoform-10 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from SKOV3 cells, using NRG1 isoform-10 Antibody. The lane on the right is blocked with the synthesized peptide.