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ELK Biotechnology

ES5692

BLNK (phospho Tyr96) Rabbit Polyclonal Antibody

BLNK (phospho Tyr96) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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BLNK (phospho Tyr96) Rabbit Polyclonal Antibody

Overview

Product name: BLNK (phospho Tyr96) rabbit pAb
Alternative Names: BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa;
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human BLNK around the phosphorylation site of Tyr96. AA range:62-111
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 50kD
GeneID（Human）: 29760
Human Swiss-Prot No: Q8WV28
Cellular localization: Cytoplasm . Cell membrane . BCR activation results in the translocation to membrane fraction.
Background: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012],
Species Reactivity: Human;Mouse;Monkey
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