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ELK Biotechnology

ES5652

NMDAε1/2 (phospho Tyr1246/1252) Rabbit Polyclonal Antibody

NMDAε1/2 (phospho Tyr1246/1252) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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NMDAε1/2 (phospho Tyr1246/1252) Rabbit Polyclonal Antibody

Overview

Product name: NMDAε1/2 (phospho Tyr1246/1252) rabbit pAb
Alternative Names: GRIN2A; NMDAR2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; N
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human NMDAR2A/B around the phosphorylation site of Tyr1246/1252. AA range:1216-1265
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
GeneID（Human）: 2903/2904
Human Swiss-Prot No: Q12879/Q13224
Cellular localization: Cell projection, dendritic spine . Cell membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane . Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. .
Background: This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Species Reactivity: Human;Mouse;Rat
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