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ELK Biotechnology

ES5584

Ksr2 Rabbit Polyclonal Antibody

Ksr2 Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Ksr2 Rabbit Polyclonal Antibody

Overview

Product name: Ksr2 rabbit pAb
Alternative Names: KSR2; Kinase suppressor of Ras 2; hKSR2
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human KSR2. AA range:671-720
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 108kD
GeneID（Human）: 283455
Human Swiss-Prot No: Q6VAB6
Cellular localization: Cytoplasm . Membrane ; Peripheral membrane protein .
Background: domain:The protein kinase domain is predicted to be catalytically inactive.,function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.,PTM:Phosphorylated on Ser-474 by MARK3.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.,tissue specificity:Mainly expressed in brain and kidney.,
Species Reactivity: Human;Mouse
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