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ELK Biotechnology

ES5548

PA26 Rabbit Polyclonal Antibody

PA26 Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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PA26 Rabbit Polyclonal Antibody

Overview

Product name: PA26 rabbit pAb
Alternative Names: SESN1; PA26; SEST1; Sestrin-1; p53-regulated protein PA26
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human SESN1. AA range:271-320
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 57kD
GeneID（Human）: 27244
Human Swiss-Prot No: Q9Y6P5
Cellular localization: Nucleus . Cytoplasm .
Background: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
Species Reactivity: Human;Mouse;Rat
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