This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009],
Western blot analysis of KB SH-SY5Y 293T lysis using Flt-1 antibody. Antibody was diluted at 1:1000
Western blot analysis of Hela KB SH-SY5Y 293T lysis using Flt-1 antibody. Antibody was diluted at 1:1000
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using VEGFR1 Antibody. The picture on the right is blocked with the synthesized peptide.