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ELK Biotechnology

ES5190

Cleaved-Factor XII HC (I20) Rabbit Polyclonal Antibody

Cleaved-Factor XII HC (I20) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Cleaved-Factor XII HC (I20) Rabbit Polyclonal Antibody

Overview

Product name: Cleaved-Factor XII HC (I20) rabbit pAb
Alternative Names: F12; Coagulation factor XII; Hageman factor; HAF
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human FA12. AA range:1-50
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
GeneID（Human）: 2161
Human Swiss-Prot No: P00748
Cellular localization: Secreted.
Background: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activat
Species Reactivity: Human;Rat;Mouse;
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