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ELK Biotechnology

ES5137

EpoR (phospho Tyr368) Rabbit Polyclonal Antibody

EpoR (phospho Tyr368) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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EpoR (phospho Tyr368) Rabbit Polyclonal Antibody

Overview

Product name: EpoR (phospho Tyr368) rabbit pAb
Alternative Names: EPOR; Erythropoietin receptor; EPO-R
Applications: WB;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human Epo-R around the phosphorylation site of Tyr368. AA range:341-390
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 55kD
GeneID（Human）: 2057
Human Swiss-Prot No: P19235
Cellular localization: Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted . Secreted and located to the cell surface.
Background: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
Species Reactivity: Human;Mouse;Rat
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