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ELK Biotechnology

ES5077

4E-BP1 (phospho Thr46) Rabbit Polyclonal Antibody

4E-BP1 (phospho Thr46) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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4E-BP1 (phospho Thr46) Rabbit Polyclonal Antibody

Overview

Product name: 4E-BP1 (phospho Thr46) rabbit pAb
Alternative Names: EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human 4E-BP1 around the phosphorylation site of Thr45. AA range:13-62
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 18kD
GeneID（Human）: 1978
Human Swiss-Prot No: Q13541
Cellular localization: nucleoplasm,cytoplasm,cytosol,protein complex,
Background: eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP1) Homo sapiens This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Mouse;Rat
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