Apaf-1 Rabbit Polyclonal Antibody

Name: Apaf-1 Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES4108
Price: 248.0 USD
Availability: InStock

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Apaf-1 Rabbit Polyclonal Antibody

Product name:	Apaf-1 rabbit pAb
Alternative Names:	APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1
Applications:	WB;IHC;IF;ELISA
Recommended Dilutions:	Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from the Internal region of human APAF1. AA range:501-550
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	135kD
GeneID（Human）:	317
Human Swiss-Prot No:	O14727
Cellular localization:	Cytoplasm .
Background:	This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Species Reactivity:	Human;Mouse;Rat

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