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ELK Biotechnology

ES3856

Prothrombin Rabbit Polyclonal Antibody

Prothrombin Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Prothrombin Rabbit Polyclonal Antibody

Overview

Product name: Prothrombin rabbit pAb
Alternative Names: F2; Prothrombin; Coagulation factor II
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Immunogen: Synthesized peptide derived from the Internal region of human Prothrombin. AA range 420-470
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 70kD
GeneID（Human）: 2147
Human Swiss-Prot No: P00734
Cellular localization: Secreted, extracellular space.
Background: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
Species Reactivity: Human;Mouse;Rat
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