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ELK Biotechnology

ES3701

WASP Rabbit Polyclonal Antibody

WASP Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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WASP Rabbit Polyclonal Antibody

Overview

Product name: WASP rabbit pAb
Alternative Names: WAS; IMD2; Wiskott-Aldrich syndrome protein; WASp
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human WASP. AA range:256-305
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 60kD
GeneID（Human）: 7454
Human Swiss-Prot No: P42768
Cellular localization: Cytoplasm, cytoskeleton . Nucleus .
Background: The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A t
Species Reactivity: Human;Mouse
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