1
/
of
1
ELK Biotechnology
SKU:ES3476
SOCS-1 Rabbit Polyclonal Antibody
SOCS-1 Rabbit Polyclonal Antibody
Regular price
$248.00 USD
Regular price
Sale price
$248.00 USD
Unit price
/
per
Shipping calculated at checkout.
Couldn't load pickup availability
SOCS-1 Rabbit Polyclonal Antibody
Overview
| Product name: | SOCS-1 rabbit pAb |
| Alternative Names: | SOCS1; SSI1; TIP3; Suppressor of cytokine signaling 1; SOCS-1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3 |
| Applications: | IF;WB;IHC;ELISA |
| Recommended Dilutions: | IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300 |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human SOCS-1. AA range:49-98 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 38kD |
| GeneID（Human）: | 8651 |
| Human Swiss-Prot No: | O15524 |
| Cellular localization: | Nucleus . Cytoplasmic vesicle . Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. |
| Background: | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Mouse;Rat |
Share
