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ELK Biotechnology

SKU:ES3473

SnoN Rabbit Polyclonal Antibody

SnoN Rabbit Polyclonal Antibody

Regular price $248.00 USD
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SnoN Rabbit Polyclonal Antibody

Overview

Product name: SnoN rabbit pAb
Alternative Names: SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 77kD
GeneID(Human): 6498
Human Swiss-Prot No: P12757
Cellular localization: acrosomal vesicle,nucleus,nucleoplasm,transcription factor complex,cytoplasm,PML body,transcriptional repressor complex,protein complex,
Background: The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Species Reactivity: Human;Mouse
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