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ELK Biotechnology

ES3382

M-RIP Rabbit Polyclonal Antibody

M-RIP Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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M-RIP Rabbit Polyclonal Antibody

Overview

Product name: M-RIP rabbit pAb
Alternative Names: MPRIP; KIAA0864; MRIP; RHOIP3; Myosin phosphatase Rho-interacting protein; M-RIP; Rho-interacting protein 3; RIP3; p116Rip
Applications: WB;ELISA;IHC
Recommended Dilutions: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen: Synthesized peptide derived from the Internal region of human M-RIP.
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 115kD
GeneID（Human）: 23164/23164
Human Swiss-Prot No: Q6WCQ1
Cellular localization: Cytoplasm, cytoskeleton . Colocalizes with F-actin.
Background: function:Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.,similarity:Contains 1 PH domain.,similarity:Contains 2 PH domains.,subcellular location:Colocalizes with F-actin.,subunit:Binds F-actin through its N-terminus (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.,
Species Reactivity: Human;Mouse;Rat
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