Rad18 Rabbit Polyclonal Antibody

Name: Rad18 Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES3304
Price: 248.0 USD
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$248.00 USD

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Rad18 Rabbit Polyclonal Antibody

Overview

Product name:	Rad18 rabbit pAb
Alternative Names:	RAD18; RNF73; E3 ubiquitin-protein ligase RAD18; Postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73
Applications:	WB;IHC
Recommended Dilutions:	WB 1:500-2000;IHC-p 1:50-300
Immunogen:	The antiserum was produced against synthesized peptide derived from human RAD18. AA range:301-350
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	56kD
GeneID（Human）:	56852
Human Swiss-Prot No:	Q9NS91
Cellular localization:	Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). .
Background:	The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008],
Species Reactivity:	Human;Rat

Western Blot analysis of various cells using Rad18 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Western Blot analysis of Jurkat cells using Rad18 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Western blot analysis of RAD18 Antibody. The lane on the right is blocked with the RAD18 peptide.
Western blot analysis of the lysates from COLO205 cells using RAD18 antibody.

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Rad18 Rabbit Polyclonal Antibody

Rad18 Rabbit Polyclonal Antibody

Overview