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ELK Biotechnology

SKU:ES3204

PIAS 3 Rabbit Polyclonal Antibody

PIAS 3 Rabbit Polyclonal Antibody

Regular price $248.00 USD
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PIAS 3 Rabbit Polyclonal Antibody

Overview

Product name: PIAS 3 rabbit pAb
Alternative Names: PIAS3; E3 SUMO-protein ligase PIAS3; Protein inhibitor of activated STAT protein 3
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human PIAS3. AA range:10-59
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 68kD
GeneID(Human): 10401
Human Swiss-Prot No: Q9Y6X2
Cellular localization: Cytoplasm . Nucleus . Nucleus speckle . Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. .
Background: This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Mouse;Rat
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