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ELK Biotechnology

ES2787

mGluR-7 Rabbit Polyclonal Antibody

mGluR-7 Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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mGluR-7 Rabbit Polyclonal Antibody

Overview

Product name: mGluR-7 rabbit pAb
Alternative Names: GRM7; GPRC1G; MGLUR7; Metabotropic glutamate receptor 7; mGluR7
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human mGluR7. AA range:866-915
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 100kD
GeneID（Human）: 2917
Human Swiss-Prot No: Q14831
Cellular localization: Cell membrane ; Multi-pass membrane protein .
Background: glutamate metabotropic receptor 7(GRM7) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found
Species Reactivity: Human;Mouse;Rat
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