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ELK Biotechnology
SKU:ES2643
IRF-3 Rabbit Polyclonal Antibody
IRF-3 Rabbit Polyclonal Antibody
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IRF-3 Rabbit Polyclonal Antibody
Overview
| Product name: | IRF-3 rabbit pAb |
| Alternative Names: | IRF3; Interferon regulatory factor 3; IRF-3 |
| Applications: | WB;IHC;IF;ELISA |
| Recommended Dilutions: | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human IRF3. AA range:362-411 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 48-55kd |
| GeneID（Human）: | 3661 |
| Human Swiss-Prot No: | Q14653 |
| Cellular localization: | Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). . |
| Background: | This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011], |
| Species Reactivity: | Human;Mouse;Rat |
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