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ELK Biotechnology
SKU:ES2595
IGF-IR Rabbit Polyclonal Antibody
IGF-IR Rabbit Polyclonal Antibody
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IGF-IR Rabbit Polyclonal Antibody
Overview
| Product name: | IGF-IR rabbit pAb |
| Alternative Names: | IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; INSR; Insulin receptor; IR; CD antigen CD220 |
| Applications: | IF;WB;IHC;ELISA |
| Recommended Dilutions: | IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human IGF1R. AA range:1126-1175 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | pro: 155kD, recetor beta: 95kD |
| GeneID（Human）: | 3480/3643 |
| Human Swiss-Prot No: | P08069/P06213 |
| Cellular localization: | Cell membrane ; Single-pass type I membrane protein . |
| Background: | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014], |
| Species Reactivity: | Human;Mouse;Rat |
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